TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations.

Further demonstration of the diversity of chromosomal changes involving 2p23 in ALK-positive lymphoma: 2 cases expressing ALK kinase fused to CLTCL (clathrin chain polypeptide-like).

Anaplastic lymphoma kinase (ALK)-positive lymphomas are characterized by expression of a hybrid protein, comprising the cytoplasmic portion of the ALK tyrosine kinase fused to a partner protein. This hybrid kinase is often encoded by the nucleophosmin (NPM) NPM-ALK fusion gene resulting from the (2;5)(p23;q35) chromosomal translocation. However, the ALK gene at 2p23 may also be involved in 2 va...

Expression of Anaplastic Lymphoma Kinase Protein in Human Breast Cancer

Background & Objectives: Anaplastic lymphoma Kinase (ALK) is a receptor tyrosine kinase involved in the genesis of several human cancers. ALK was initially identified because of its involvement in anaplastic large cell lymphoma (ALCL). ALK is believed to foster tumorigenesis following activation by autocrine and/or paracrine growth loops. Studies reveal that the presence of anti-ALK antibodies ...

ALK- negative Anaplastic Large Cell Lymphoma of Bone

The origins of ALK translocations.

Translocations involving the anaplastic lymphoma kinase (ALK) gene locus on chromosome 2p23 were first described in anaplastic large cell lymphoma (ALCL). Although most commonly fused to the nucleophosmin (NPM1) gene on chromosome 5q35, which results in the t(2;5)(p23;q35)/NPM1-ALK translocation, several other ALK translocation partners have meanwhile been identified. Furthermore, apart from AL...

Epithelioid inflammatory myofibroblastic sarcoma harboring ROS1-TFG fusion; a case report

Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is a rare and aggressive variant of inflammatory myofibroblastic tumor (IMT). ALK-RANBP2 fusion is one of the supposed mechanisms for the aggressive biological behavior of this tumor. To the best of our knowledge, we report the first case of EIMS carrying ROS1-TFG fusion which affected a 16 year-old male. The patient presented abdominal pa...